Mélisande Blein-Nicolas obtained a PhD in Biology and Agronomy (Agrocampus Ouest, Rennes, France) in 2007. During her PhD and first post-doctoral position at CIRAD (Biology and Genetics of Plant Parasite laboratory, Montpellier, France), she worked on biotic stress resistance mechanisms in wheat and rice using functional genomics approaches. At the beginning of 2010, se joined the Quantitative Genetics and Evolution –Le Moulon laboratory (GQE-Le Moulon, Gif-sur-Yvette, France), where she worked as post-doctoral fellow until 2015. During this period, she successively worked on heterosis for protein abundance in yeast, genetic determinism of maize leaf protein expression under normal and water deficit conditions and heterosis for protein abundance in sunflower under normal and water deficit conditions. In 2015, she obtained a permanent position of research engineer on the PAPPSO proteomics facility hosted at the GQE-Le Moulon laboratory, where she was involved in the management of the facility and in the design and implementation of developments for the analysis of proteomics data. In parallel, she developed a research program aiming at deciphering the genotype/phenotype relationship in maize using system approaches based on multi-omics data integration. Since 2022, she is the scientific head of PAPPSO. Her current research activities focuses on the genetic control and plasticity of the molecular networks involved in the construction of ecophysiological traits related to drought tolerance in maize.